Seminar in Department of Chemistry : Rational Design of Onium-tagged Prolines as Organocatalysts for the Asymmetric Aldol Reaction

Speaker       : Dr. Easwar Srinivasan, Assistant Professor, Department of Chemistry, Central University of Rajasthan

Seminar Title: Rational Design of Onium-tagged Prolines as Organocatalysts for the Asymmetric Aldol Reaction.

Venue           :  L3

Date & Time : 04th February, 2013, from 3:00 pm to 4:00 pm

 

 A modular approach to catalyst hydrophobicity led to the design of a water soluble organocatalyst that could function in a highly efficient and stereoselective fashion for the asymmetric aldol reaction in a biphasic aqueous environment. The key to the design of the catalyst was the modulation of its partition coefficients in different aqueous biphasic environments. The new catalyst, consisting of a hydrophilic cation and lipophilic anion, fulfilled the solubility requirements needed to couple efficiency, stereoselectivity and catalyst recyclability in asymmetric aldol reactions under aqueous biphasic conditions.